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In insulin-resistant states such as T2D and obesity, hyperinsulinemia contributes to macrophage polarization from the anti-inflammatory M2 phenotype toward the pro-inflammatory M1 phenotype [32, 52, 53]

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Two years ago, researchers examining the link between GLP-1 and substance abuse began to publish large, observational studies showing that patients taking GLP-1s for their prescribed purposes incidentally reported less alcohol, opioid, cannabis and cigarette use and had a lower risk of developing a substance use disorder

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