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Description
| Nature Made
Through downregulating monocyte chemoattractant protein-1 expression, semaglutide treatment, an FDA-approved GLP-1 RA medicine targeting Type II diabetes mellitus (T2DM) (Christou et al., 2019), inhibited monocyte migration and infiltration from the circulatory system to inflammatory regions (Pontes-da-Silva et al., 2022)
MRI, Magnetic Resonance Imaging
The Surmount-5 trial had 25% and 30% weight loss reported, and max tolerated dose of tirzepatide caused 36% and 22% of patient hitting those two marks respectively
doi: 10.1016/0167-4838(82)90041-3
