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In 2011, the FDA imposed dose limits on citalopram due to the risk of QTc prolongation: 40 mg/day for adults and 20 mg/day for those aged 60 years, along with ECG monitoring for high-risk patients [21]

Increase fiber intake gradually to support regularity Aim for 64 to 80 ounces of water daily Magnesium supplements can help with constipation Probiotics may improve overall digestive comfort Light walking after meals aids digestion Avoid artificial sweeteners which can worsen GI symptoms Fatigue is reported by some women, particularly during dose escalation

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Moreover, women with UFs have greater expression of MCP-1, which is associated with a higher density of macrophages and PGF2 and an inflammatory effect in the endometrium