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A pharmaceutical composition comprising Semaglutide and one or more permeation enhancers selected from Labrasol, Capryol, 5-CNAC, 5-CNAC Disodium, Salcaprozate Sodium (SNAC), Vitamin E TPGS, Gelucire, Soyabean lecithin, Lysine, Phenyl alanine, Tryptophan, Sodium caprylate, Sodium caprate, Capsaicin analogue, Sodium laurate, Sodium chenodeoxycholate, Propyl gallate, Sodium octanoate, Sodium nonanoate, Sodium decanoate, Sodium undecanoate, Sodium dodecanoate, Sodium tridecanoate, Dodecyl maltoside, Tridecyl maltoside, Tetradecyl maltoside, Sucrose mono dodecanoate, Sucrose mono-tridecanoate, Sucrose mono-tetradecanoate, Sodium dodecyl sulfate, Sodium hexanoate, Sodium heptanoate, Sodium tetradecanoate, and combinations thereof

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