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This risk was particularly concentrated in patients with pre-existing retinopathy and those experiencing rapid reductions in HbA1c

According to research data NCI-H716 cells were treated with three dosages: 100, 200, and 500 g/mL in db/db mice, resulting in a dose-dependent increase in GLP-1 secretion, with all concentrations significantly enhancing GLP-1 secretion in the human L cell line [22]

In isolated murine -cells, GLP-1 stimulates exocytosis of the insulin granules and this can be blocked by co-treatment of GLP-1 with the adenylate cyclase inhibitor MDL 12330A [508]

Potential benefits need to be weighed against the risk of hypoglycemia and lack of long-term data

The incretin effect is very brief because it remains active 12 min after its secretion and is then inactivated by the enzyme dipeptidylpeptidase-4 (DPP-4) [7]