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[PMC free article] [PubMed] [Google Scholar] 95.Staller K., Thurler A.H., Reynolds J.S., Dimisko L.R., McGovern R., Skarbinski K.F., Kuo B

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Hormonal fluctuations are another key consideration: Rapid weight loss can significantly alter SHBG and free testosterone levels, potentially leading to symptoms of androgen excess or deficiency even when the prescribed testosterone dose remains unchanged

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By targeting both receptors, Tirzepatide has a stronger and more sustained effect on insulin sensitivity