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CrossRef Insulin release: the receptor hypothesis Willy J

This is because excess fat mass doesnt increase protein needs the way muscle mass does

Reduced lipogenesis: Glucagon suppresses enzymes that drive fat and cholesterol synthesis in the liver

GLP-1R expression on intraepithelial lymphocytes and gut macrophages likely mediates these local effects, supporting the therapeutic rationale for GLP-1R-targeted nanotherapies in reducing steroid dependence [400, 401]

The discovery of insulin in 1921 transformed diabetes from a fatal disease into a manageable condition, but it also exposed the inconvenience and limitations of parenteral administration for chronic therapy