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Other higher-risk groups include patients who are currently up-titrating, those with severe nausea or vomiting, known gastroparesis, and individuals undergoing urgent abdominal or airway procedures

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Secondary endpoints included a thorough assessment of the safety profile, monitoring for common adverse events such as gastrointestinal symptoms, and determining the proportion of participants who achieved significant reductions in body weight

These include type 2 diabetes and prediabetes (because GLP-1 medications affect blood sugar), thyroid conditions (because of the boxed warning about medullary thyroid carcinoma), a history of pancreatitis (because GLP-1 medications carry a small risk of pancreatitis), gastroparesis or other gastric motility disorders (because GLP-1 medications slow gastric emptying), and any history of eating disorders (because the appetite-suppressing effects of GLP-1 medications require careful management in patients with disordered eating)