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Within minutes after a meal, GLP-1 is released from the L cells in the ileum and colon and regulates insulin secretion in a glucose-dependent manner
They notice extra fat around their stomach, arms, stomach, and neck

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It is especially important during weight loss because the goal is to lose excess fat while protecting useful muscle

[DOI] [PubMed] [Google Scholar] 9.Lim S., OReilly S., Behrens H., Skinner T., Ellis I., Dunbar J.A