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"The companies and the FDA, no one's identified an endgame with these drugs," Kessler says

The decision to use these treatments should involve a comprehensive discussion of individual risk factors, family history, and the balance between metabolic benefits and potential concerns

The long-term effects of drugs that target systemic inflammation and metabolic pathways on autoimmune skin diseases needs further investigation

They have been shown to have multiple pivotal roles including GI immune regulation, motility and maintaining the intestinal epithelial barrier, as well as being a conduit for the gutbrain axis