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Similarly, the fetal effects of exenatide, which has a negligible fetal-to-maternal peptide concentration ratio during ex vivo human placental perfusion, are probably due to maternal side effects (34)

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So far, the largest molecule known to cross the BBB through a nonsaturated mechanism (active transport or specific receptor-mediated pathways rather than passive diffusion) is CINC-1, a cytokine involved in regulating inflammation and immune responses, with a molecular weight of 7.8 kDa