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Macro vascular complications are still the primary cause of death in patients with T2DM.Glucagon like peptide-1 receptor agonists (GLP1-RAs) are a new class of Injectable Anti-diabetes Agents (IADA) that provides blood glucose control with weight reduction ability, systolic blood pressure reduction and a noticeable improvement of lipid profile

In high-fat diet-induced diabetes mice, administration of liraglutide activated pancreatic and duodenal homeobox-1 (Pdx-1), an essential regulator of proliferation and function of pancreatic -cells [56]

40 The phosphorylation-mediated signalling response we observe in the sinus node resembles the signalling response elicited by increased levels of cAMP and the canonical signalling mechanism associated with activation of the GLP-1 receptor, e.g

Weir GC, Bonner-Weir S

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