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For the first time in the history of obesity medications we see weight loss efficacy of a magnitude that might raise concern about excessive loss of lean body tissue due to the initial pronounced reduction in energy intake and subsequent risk of protein deficiency

Preserved kidney function: The rate of decline in estimated glomerular filtration rate (eGFR, a measure of kidney function) is slowed

Statins are relatively inexpensive, and patients may see them as free because the Affordable Care Act (ACA) mandates that the co-pay on most strengths is $0, further driving their widespread utilization

and thereafter, administer two tablets twice daily

Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism