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and marketed under the trade name of Mounjaro, a first-in-class Twincretin, which is a dual activator of GIP and GLP-1 receptors, resulting in improved blood sugar control in type 2 diabetics The review covered the comprehensive insight on the drug discovery journey of tirzepatide

The molecule is classified as a triple receptor agonist because it interacts with three endocrine receptors involved in metabolic regulation: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

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Long-term semaglutide use for weight management shows generally favorable safety data in clinical trials, though individual outcomes depend on baseline health status, existing conditions, and genetic predispositions