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In men, this allows Tamoxifen to: Block estrogen activity in breast tissue (preventing gynecomastia) Stimulate LH and FSH release via central feedback disruption Increase natural testosterone production Support bone and lipid health through partial agonist activity in the liver and skeletal tissue Tamoxifen is a non-steroidal SERM that competes with estrogen for receptor binding in estrogen-sensitive tissues, offering tissue-selective antagonism or agonism depending on the site. Kicman, British Journal of Pharmacology Tamoxifen in Women: Clinical Use and Mechanism of Action Tamoxifen was originally developed as a treatment for estrogen receptor-positive (ER+) breast cancer in women , and it remains one of the most widely prescribed drugs in oncology today