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Description
Semaglutide works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which sends signals to the part of the brain that regulates appetite and food intake

Different receptor targets mean different downstream effects

GLP-1 agonists work through distinct mechanismsenhancing glucose-dependent insulin secretion, suppressing glucagon, delaying gastric emptying, and promoting central satiety signaling

doi: 10.1038/s41467-017-02294-6

Since every person responds to medications differently, more research is needed to understand why some experience irritability while others do not