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Exendin-4 was ultimately synthesized to Exenatide, a GLP-1RA with a half-life sufficient to permit clinical use in treating type 2 diabetes, the first in a new generation of drugs that followed

As mentioned above, inflammatory responses and immunity are involved in the development and onset of depression ( Figure 2 )

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Other reviewed options include Advanced Bionutritionals GLP-1 Plus , Tranont GLP-1 , RESM GLP-1 Postbiotic , and Replenza GLP-1

Abbreviations GLP-1 RAs: Glucagon-like peptide-1 receptor agonists T2DM: Type 2 diabetes mellitus COPD: Chronic obstructive pulmonary disease BMI: Body mass index HbA1c: Glycated hemoglobin RR: Relative risk CI: Confidence interval RCT: Randomized controlled trial CVOT: Cardiovascular outcome trial PRISMA: Preferred reporting items for systematic reviews and meta-analyses References Zar HJ, Ferkol TW