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The SURMOUNT trial program demonstrated that tirzepatide produces approximately 20.9% average weight loss at maximum doses, representing a 6 percentage point improvement over semaglutide

At one year, compared with placebo, weight loss was 4.1 kg in the exercise group, 6.8 kg in the liraglutide group, and 9.5 kg in the combination group, highlighting the additive benefits of combining pharmacotherapy with exercise [6]

doi: 10.1016/j.cmet.2018.03.001 97 HolscherC

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