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After discontinuation, there was a pronounced rebound in weight (MD=4.13 kg, 95% CI: 1.60 to 6.65), BMI (MD=0.84 kg/m2, 95% CI: 0.37 to 1.32), WC (MD=3.64 cm, 95% CI: 2.27 to 5.01), and HbA1c (SMD=0.69, 95% CI: 0.50 to 0.89)

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Women benefit most when we treat menopause as the metabolic inflection point it isnot just prescribing GLP-1s in isolation, but considering hormone therapy, addressing sleep disruption (which drives cortisol and undermines any weight loss effort), and building strength to counter the lean mass loss these medications can cause