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The FDA and other regulatory agencies have conducted extensive reviews of safety data from clinical trials and post-marketing surveillance

Being keto-adapted primes the metabolic pump

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This was emphasised in the CANTOS trial, in which a monoclonal antibody targeting IL-1 in individuals with established atherosclerotic CVD and evidence of systemic inflammation reduced the risk of major adverse cardiovascular events (MACE) by 1517%, an effect that was likely to be mediated by reductions in serum CRP concentrations [80, 81]

However, both groups experienced similar levels of weight loss (3.24 vs