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We primarily examined if GLP-1RAs can achieve corticosteroid-free clinical remission without altering the underlying immunosuppressive therapy in IBD, and secondarily if GLP-1RA therapy can improve IBD outcomes such as reducing corticosteroid use, hospitalizations, surgeries, and advanced therapies

But retatrutide may be even more effective , for several reasons: Glucagon receptor activation promotes hepatic fat oxidation Reduces liver fat accumulation more robustly Improves liver enzyme levels (ALT, AST) In a subgroup analysis of the retatrutide Phase 2 trial: Patients with suspected NAFLD showed a 70%+ reduction in liver fat content , measured by MRI-PDFF These effects surpassed the reductions seen with tirzepatide and semaglutide in comparable studies Another study showed that 93% of patients on the highest dose of retatrutide had 100% resolution of fatty liver

However, these risks were comparable in other instances with tirzepatide and controls (placebo, insulin, and GLP-1RA) in subgroup analyses according to tirzepatide dose (Table 2)

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GCGR activation increases thermogenesis and hepatic fat oxidation effects that complement the appetite and insulin secretion effects of GLP-1R and GIPR activation, and which researchers study as a distinct and additive mechanism contributing to Retatrutides overall metabolic profile