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The reported discontinuation rates and use of rescue medication in GLP1 RA trials are overall lower than the estimates reported in our study

Potential Mental Health Effects of GLP-1 Treatment Clinical experience and emerging research suggest that GLP-1 receptor agonists may influence mental health in various ways, though the evidence base remains limited and findings are mixed

and sensitivity analyses comprising restriction to new-user designs to avoid prevalent-user bias, implementation of lag periods of 1-2 years to address reverse causation (prodromal dementia depression SSRI), and use of negative control outcomes, such as fractures, to detect unmeasured confounding

An a priori sample size calculation was performed using repeated measures, within factor ANOVA

Patients using oral hormonal birth control should discuss this with their prescriber