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These symptoms may indicate complications requiring medical assessment

Tirzepatide versus dulaglutide Among patients in the expanded population who initiated tirzepatide or dulaglutide, the 1-year risk for the primary endpoint including all-cause mortality in the tirzepatide group was 1.4% (95% CI 1.3% to 1.6%) versus 1.8% (95% CI 1.5% to 2.0%) for dulaglutide

However, it is not recommended for individuals with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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The GLP-1 receptor pathway remains active, but lower exposure levels may produce smaller or less predictable metabolic effects because those ranges have not been validated in large trials
