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Senolytics, certain peptides, and some supplement combinations have early-stage human research suggesting potential benefit, but large-scale controlled trials are not yet available

Anecdotal reports also mention low energy or brain fog at higher doses, likely resulting from chronically reduced caloric intake

Frontiers in Physiology , 12, 688

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The catch for semaglutide users is fermentation: inulin is highly fermentable and high-FODMAP, so on an already-slowed gut it can produce gas and bloating that drives people off it before they feel the benefit