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JAMA Psychiatry article:Repurposing Semaglutide and Liraglutide
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Although canonically GLP1Rs signal through the stimulatory alpha Gs protein, we find that semaglutide utilizes both Gs- and Gq-signaling pathways in GLP1Rs in the area postrema (AP)the primary site of semaglutide action in the brainto differentially regulate neuronal activation across distinct neuronal clusters
However, evidence of this is still lacking in humans
