semaglutide news october 2025 GLP-1 overdoses have been skyrocketing, with poison centers seeing a nearly 1500% increase in calls related to overdose or side effects of injectable weight-loss drugs since 2019, according to US National Poison EUREKA! The Top Endocrine Science

For example, gastro-oesophageal reflux disease (GORD) is listed as a common side effect (affecting up to 1 in 10 people) with semaglutide (Wegovy), while dyspepsia (indigestion) is common with several agents in this class

When markers like blood sugar and cholesterol improve, it reduces the risk of chronic diseases that plague millions

By reducing leptin resistance, it helps the brain recognize fullness and curbs overeating

Tell your health care provider if you have stomach problems that are severe or will not go away serious allergic reactions

Open questions The authors cautioned that the trial was a small pilot study and not randomized, adding that all participants had obesity