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In phase 3 trials, maximal dose retatrutide demonstrated 29% placebo-adjusted weight loss at 68 weeks (albeit with higher discontinuation rates than semaglutide and tirzepatide)
DOI: 10.1111/obr.13064 Garvey W.T
Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP (1-30) and GIP (1-42) in high-fat fed mice
These products are regulated as dietary supplements with associated labeling and manufacturing requirements
The study included 588,168 participants
