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Since topics may be intrinsically distinguished by other embedded features from the model (e.g., linguistic style, tone) rather than meaningful content, we cluster the cumulative term-frequency inverse-document frequency (c-TF-IDF) representation of these topics using Spectral Clustering to find overarching themes of discussion (groups)

132 Glutamate receptors, including the amino-3-hydroxy-5-methyl-4-isoxazolepro-pionicacid (AMPA) and N-methyl-D-aspartate (NMDA) receptors, mediate excitatory synaptic transmission in the CNS, and its expression in the postsynaptic membrane is associated with LTP and LTD and is involved in the regulation of learning and memory activities

Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings

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