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body weight (mean reduction of 1 3 kg at 2 years)

Importantly, GLP-1 receptors are found not only in neurons but also in glial cells, which mediate its effects on brain health by regulating energy balance and maintaining neural circuits

The peptideantibody conjugate accesses the CNS via CVOs, activating downstream brain regions involved in appetite regulation

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Variants such as FTO rs9939609 and MC4R rs17782313 relate to baseline appetite regulation and weight susceptibility, potentially informing whether strict carbohydrate restriction aligns with your biological profile