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The primary exposure examined in the study was GLP-1 agonist use, which included semaglutide, liraglutide, and others

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This meta-analysis of 18 cohort studies with more than one million participants concluded that combining an SGLT-2 inhibitor with a GLP-1 receptor agonist is associated with better cardiovascular, heart failure and kidney outcomes

GLP-1 RAs are drugs that imitate the function of natural GLP-1, a hormone in the intestine that controls glucose metabolism and feelings of fullness

However, because these reports are voluntary, they cannot be used to determine exactly how much the medication increases risk compared to other factors like age or family history