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23 Market exclusivity for top-selling brand-name drugs has a median of about 12-14 years, 24 but longer periods have been observed for inhalers (median of 16 years) 1012 and insulin products (median of 17 years)

Read the full case report: #OpenAccess Authors: Basil Nduma, MD, MSHI, Sai Nikhitha Malapati and Veeranna Vibhuti Severe hypercalcemia in CKD patient on GLP-1/GIP agonist and hydrochlorothiazide As tirzepatide and other GLP-1/GIP agonists gain traction in managing type 2 diabetes and obesity, a new case report describes a critical presentation of severe hypercalcemia following co-administration with hydrochlorothiazide in a patient with pre-existing CKD

Tirzepatide is recommended by NICE for managing type 2 diabetes in specific circumstances, typically when other treatments have not achieved adequate glycaemic control

Clinical trials for Semaglutide demonstrated an average of 15% body weight reduction, while participants using Tirzepatide have reported up to 22.5% weight loss

Reybelsus (available in some countries) is an oral formulation of semaglutide
