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GLP-RA developers have applied various half-life extending strategies and some of them have successfully resulted in FDA-approved diabetes products (Table 1)

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E.ZhangQ.AbdulkaderF.BengtssonM.et al (2010)

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), medications routinely used in managing type 2 diabetes and obesity, have sparked interest due to their potential influence on circulating testosterone levels [2]