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This has a significant toll on life expectancy, which is shown to be reduced by 7 years at the age of 40 years [3]

318,322 Macrophages have two polarization states, M1 typically has pro-inflammatory properties, while M2 has anti-inflammatory properties
Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, et al

Diabetologia 2002;45:195202 [DOI] [PubMed] [Google Scholar] 20.DeYoung MB, MacConell L, Sarin V, Trautmann M, Herbert P