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J.JinH.LeeJ.JuJ

122 This paradoxical response of SREBP-1c and ChREBP in hepatic IR is probably due to many branch effectors (including PI3K/AKT, AMPK, mTORC1, and FOXO1) involved in the hepatic glucose and lipid metabolism

Impact on the Digestive System 4

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A characteristic feature is the loss of interstitial cells of Cajal, likely secondary to immunological changes, such as a shift from protective M2 to M1 macrophages and impaired regulation of haem oxygenase-1, leading to oxidative stress
