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Moreover, vagal afferent neurons project to GLP-1 producing neurons in the caudal brainstem which secrete GLP-1 into hypothalamic nuclei which regulate energy metabolism [103]

We acknowledge that there were some differences in the comparison between GLP-1RAs and other glucose-lowering agents, particularly concerning HbA 1c levels, the use of insulin and the use of SGLT2 inhibitors, which may have influenced the results

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