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It was also found that GLP-1R agonists decrease many proinflammatory biomarkers usually responsible for the development of diabetic nephropathy such as TNF-alpha, fibronectin, monocyte chemoattractant protein-1 (MCP-1) and alpha-smooth muscle actin [72]

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8 Weight regain is a common reality upon cessation of these medications if underlying lifestyle patterns have not shifted