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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Yang L, Shao J, Bian Y, Wu H, Shi L, Zeng L

Some users report experiencing anhedonia (a lack of pleasure in previously enjoyable activities), as their brain's normal pathways for reward and satisfaction are disrupted

The FDA does not approve compounded versions of semaglutide or tirzepatide and has issued warnings about them in 2026

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Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: A 24-week, randomized, open-label, active-controlled study (GetGoal-X) Diabetes Care