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Over the course of 6 months, patients can expect to lose between 10% to 15% of their body weight, with the most significant results occurring between 12 to 16 weeks of consistent use

Individuals who may be at greater risk include: Those with a pre-existing diagnosis of osteoarthritis, rheumatoid arthritis, or other inflammatory joint conditions Patients with obesity-related joint loading, particularly affecting the knees, hips, and lower back Older adults, in whom musculoskeletal complaints are more prevalent at baseline Individuals experiencing rapid weight loss, which may transiently alter joint mechanics and gait, particularly in the lower limbs this is a theoretical consideration based on general musculoskeletal principles rather than retatrutide-specific evidence Significant weight reduction one of retatrutide's primary therapeutic effects is generally associated with reduced mechanical load on weight-bearing joints , which may improve joint symptoms over time in individuals with obesity-related arthropathy

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Movement is so much more than just about burning caloriesit lowers stress, boosts lymphatic movement, improves mood, builds muscle, and more

The placebo group saw only a 2.4% mean decrease in weight.This makes it important to have a willingness to incorporate a healthy diet and regular exercise into your life if you are considering beginning treatment