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Discontinuation rates due to AEs were 12.2% and 18.2% with Retatrutide 9 mg and 12 mg, respectively, compared to 4% with placebo

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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

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Understanding when to pause treatment, how GLP-1 compounds work during conception, and medical safety protocols helps patients make informed decisions about weight loss therapy and family planning

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Losing 30 pounds is a significant milestone that typically takes 46 months on semaglutide or 35 months on tirzepatide, depending on your starting weight, dosing schedule, and metabolic genetics

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