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Chronic low-grade inflammation has a documented role in promoting insulin resistance and other metabolic derangements in obesity and obesity-related conditions, including the metabolic syndrome, type 2 diabetes, cardiovascular disease and non-alcoholic steatohepatitis (Pavlov & Tracey, 2012)

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Main mechanism Inhibits the reuptake of dopamine, norepinephrine, and serotonin in the brain (a triple monoamine reuptake inhibitor, or SNDRI)

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