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Description
Common side effects may include: Nausea Constipation Diarrhoea Stomach discomfort Reduced appetite These effects are often temporary and may improve as treatment progresses
There are additional potential dangers related to this medication, including pancreatitis and gallbladder disease
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The antioxidant role of metformin is carried out through several mechanisms: (1) direct trapping of hydroxyl radicals, (2) activation of antioxidant enzymes such as catalase, which is the main decomposer of H 2 O 2 , and (3) reducing the transcription and activation of NADPH oxidase 4 (NOX4), which is a major source of oxidative stress [115]

This step-up approach is important because it helps your body adjust to the medication without overwhelming it and reduces the risk of side effects
Retrospective studies of GLP-1 therapy support the role of structured exercise programs, e.g., 360 min/week with an emphasis on strength exercises to preserve fat-free mass [161]