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(28) GLP-1 Agonists and Surgical Outcomes Pre-Clinical Studies Liu et al

The key mechanisms are: Sustained appetite suppression and reduced caloric intake Reduced dietary variety and food volume Delayed gastric emptying Gastrointestinal side effects Rapid weight loss and lean mass reduction Potential alterations in gut microbiota Each pathway contributes differently

Variants in GLP1R, GIPR, FTO, and MC4R genes can influence how your body responds to GLP-1-based therapy

There is a complex interaction between host genetic and metabolic makeup, diet, and microbiota (Figure 5)

Nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion (dyspepsia), and stomach (abdominal) pain have been reported