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Numerous studies have documented a high prevalence of IR in individuals with major depressive disorder and bipolar disorder, even in the absence of obesity or overt metabolic disease [36,37]

Anyone with a health condition that might have made it unsafe or challenging to participate was left out of the semaglutide clinical trials, for example, according to the study protocol, a precaution similar to other clinical trials

[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Gejl M, Egefjord L, Lerche S, et al

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