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Now considered a landmark in the GLP-1 field, the article listed Mojsov as the first author and Habener as the last, a position customarily reserved for the senior author (Couzin-Frankel 8 Sept 2023

Staying hydrated helps with digestion and can keep some of the side effects of Rybelsus, like bloating or nausea, in check

When interpreted with a qualified healthcare provider, these predispositions can help explain why some patients respond robustly to GLP-1 therapy at lower doses, while others may require higher doses or combination approaches

In intestinal L-cells, proglucagon is cleaved by prohormone convertase 1/3 (PC1/3) to generate GLP-1, along with other peptides such as GLP-2, oxyntomodulin, and peptide YY

Cohort design, covariates, and outcomes This retrospective, propensity-score-matched cohort study included obese patients (BMI 27 kg/m) initiating Tirzepatide, Semaglutide, Phentermine/Topiramate, Naltrexone/Bupropion, or Phentermine from November 1, 2023, through April 31, 2025