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subsequently confirmed this association in a large multicenter database study of 37.1 million adults, but the incidence was low at 14.5 per 100,000 person-years among semaglutide users, and there was only a modest increase in risk attributable to semaglutide (90)

When comparing tirzepatide vs diet and exercise results , the medication acts as a powerful catalyst, making the adherence to diet and exercise significantly easier by reducing hunger and cravings, thereby enhancing the overall results

In addition, the activation of GLP-1R was shown to promote synaptic plasticity and axonal growth (90)

Am J Physiol Physiol 297(6):F1647F1655 Meier JJ (2012) GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus