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Although the majority of absorbed Trp is directed into the kynurenine pathway via indoleamine 2,3-dioxygenase (IDO) in extrahepatic organs, or tryptophan 2,3-dioxygenase in the liver, culminating in NAD + synthesis [19], around 3% of absorbed Trp is converted into serotonin [20]

85 Dulaglutide 1.5 mg has demonstrated non-inferiority in diabetes control compared to liraglutide 1.8 mg, and comparable weight reduction efficacy to oral SEMA (Orforglipron) 3 mg

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Future directions and research gaps Although GLP-1 therapies have revolutionized obesity and diabetes management, important knowledge gaps remain in optimizing their long-term safety, tolerability, and body composition outcomes

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