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Moreover, in AD/STZ mice, DA4-JC reduces microglia and astrocyte activation (Shi et al., 2017)
62 In SURPASS-5, when tirzepatide was added in people who were already on insulin glargine, it led to 2.23% to 2.59% reduction in HbA1c versus 0.93% with placebothis improvement in glycemia was also associated with a reduction in insulin use
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This can usually be addressed through modest dietary adjustments
