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Including these benefits in the microsimulation model would have made the GLP-1 drugs look a bit more cost-effective

Considering that around one-third of the global population and 42.4% of US adults are classified as obese, these medications have a significant market [6, 7]

The theoretical benefits of delaying onset of kidney failure, in terms of years gained, for patients in FLOW treated with semaglutide vs placebo, if the amelioration of eGFR decline occurs a constant rate with semaglutide, is shown in Figure 4

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Additionally, we are unsure whether once-weekly dulaglutide therapy can further improve patient satisfaction in T2DM compared with once-daily liraglutide therapy [15, 16]