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In humans, intravenous infusion of a somatostatin analog, octreotide, 30 min prior to carbohydrate meal (Hycal) significantly impairs insulin, GLP-1, and GIP secretion in both lean and obese women, yet post-heparin LPL activity (contributions from adipose, skeletal and cardiac tissue) is unchanged 1.5 h post-peak insulin in lean and obese women (Ranganath et al., 1999)

Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus

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this results in weight loss, which in its turn improves glycaemic and insulin parameters (which are inter-related)

And once that plan is in place, stay in touch