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Semaglutide's evidence base is much newer and arguably more robust for the chronic weight-management context: STEP-1 (NEJM, 2021) showed mean ~15% body weight reduction at 68 weeks on semaglutide 2.4 mg weekly

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Also, a meta-analysis reported that hypothyroidism was associated with a higher risk of thyroid cancer within the first 10 years of follow-up ( There may be several reasons for such a significant increase in the GLP-1RA-associated thyroid tumor reporting rate

Diabetes medications and cancer risk associations: a systematic review and meta-analysis of evidence over the past 10 years

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